n carbamyl l glutamic acid

As advanced biochemistry and industrial process engineering accelerate, n carbamyl l glutamic acid (N-Carbamylglutamic Acid, NCG) emerges as a pivotal molecule. It finds extensive utility in biochemical synthesis, animal nutrition, pharmaceuticals, and specialty chemicals. This article presents an all-encompassing deep dive into the latest industry trends, Mrket data, production process, technical parameters, authoritative standards, and proven application scenarios. High purity n carbamyl l glutamic acid crystalline powder Industry Trends & Market Overview The global n carbamyl l glutamic acid market is forecast to grow at a CAGR of 6.1% from 2024 to 2030, driven by rising applications in animal nutrition, enzyme engineering, and rare metabolic therapy (source: Grand View Research ). The demand is especially notable in large-scale poultry, swine, and ruminant feed production as well as in pharmaceutical intermediates synthesis. Projected Market Value (2024): USD 35+ million Key Consumption Regions: China, North America, EU Primary Applications: Urea cycle disorder treatment, animal feed additive, chemical intermediates Regulatory Acceptance: Approved by FDA, EU EFSA, GB Standards, ISO 9001:2015 certified manufacturers What Is Glutamic Acid Used For? Glutamic acid is an essential α-amino acid found widely in proteins, central to nitrogen metabolism and neurotransmission. In the industry, glutamic acid and its derivatives, chiefly n carbamyl l glutamic acid , are utilized for: Enhancing metabolic function and growth (animal feed, veterinary use) Therapeutic agent for urea cycle deficiencies (clinical settings) Precursor for pharmaceutical APIs such as L-ornithine, L-arginine Stabilizing agents in enzyme-formulation industries Chemical building block for synthetic resins and functional materials Expert Quotable: "N-Carbamyl-L-Glutamic Acid uniquely mimics endogenous N-acetylglutamate, activating carbamoyl phosphate synthetase and restoring urea cycle efficiency, especially in birds and mammals." — Prof. Li Han, Biochemical Engineering, Nature Scientific Reports Manufacturing Process: n carbamyl l glutamic acid Production Flow Raw Material Selection → Synthesis/Carbamylation → CNC-Precision Filtration → Recrystallization → Drying & Quality Inspection → Packaging (ISO 9001) * Advanced material purification steps utilize food/pharma-grade reactors and computer-controlled (CNC) filtration for maximum purity and batch consistency. International ISO, ANSI, and local GB standards are met and traceably documented. Material: Pharma/Feed grade Glutamic Acid (≥99%) Manufacturing: Carbamylation with strong base, advanced distillation, and controlled crystallization (fully enclosed GMP workshops) Equipment: Stainless steel (316L), precision filtration (membrane pore ≤0.22μm), CNC automation Testing: HPLC analysis, moisture, heavy metal, and microbial limits per ISO 17025 Certifications: ISO 9001:2015, ISO 22000, FDA DMF Registered, HACCP, FAMI-QS Technical Parameters of n carbamyl l glutamic acid NCG Product Technical Specifications (Typical) Parameter Specification Test Method Standard Reference Appearance White crystalline powder Visual, Q/FA-2023 ISO 9155-2016 Purity (HPLC) ≥ 99.0% HPLC, UV 210nm USP/Ph. Eur Water Content ≤ 1.0% Karl Fischer ISO 760 Heavy Metals < 10ppm AAS USP <231> pH (1% sol.) 6.5 – 7.5 Potentiometry GB/T 9724 Loss on Drying ≤ 1.0% VAC Oven ISO 712 Residue on Ignition ≤ 0.1% Muffle Furnace ISO 4316 Arsenic < 2ppm AAS USP <211> Microbial Limits Conforms Culture/USP ISO 4833 Figure 1: Trend chart of HPLC Purity (%) versus production batches (2020-2024) Comparative Table: NCG vs. Conventional Glutamic Acid Additive Attribute N-Carbamyl-L-Glutamic Acid (NCG) Standard Glutamic Acid Bioactivity Direct activation of carbamoyl phosphate synthetase (rate-limiting for urea cycle) Amino donor, limited metabolic impact in urea cycle Stability Highly stable, low hygroscopicity Moderately stable, moisture-sensitive Usage Concentration Low (0.05–0.1% of feed weight) Moderate (0.3–1.0% typical) Passed Standards ISO 9001/FDA/EFSA/GB ISO 9001/GB Regulatory Limitations Rare, globally accepted Certain feed restrictions (EU/EAEU) Delivery Form Fine powder/granules for direct mixing Powder/Crystal, often requires predilution Typical Application Urea cycle disorder therapy, swine/poultry/bovine feed General amino acid supplement Left: Purity level market share; Right: Top 5 industrial application share for n carbamyl l glutamic acid Typical Application Scenarios Poultry & Swine Feed : Multiple studies demonstrate that supplementing animal feed with n carbamyl l glutamic acid can improve feed conversion ratio by 6–11% in broilers and piglets, reduce ammonia excretion, and enhance protein utilization. (Source: Animal Feed Science and Technology, 2018 ) Feed-grade N-Carbamyl-L-Glutamic Acid: what is glutamic acid used for Medical/Pharma : In rare urea cycle disorders (NAG synthase deficiency), NCG is an essential orphan drug for metabolic rescue. Clinical trial: NCG reduced plasma ammonia by 64%, normalizing levels in >95% patients within 72 hr ( Am J Med Genet, 2022 ). Chemical & Enzyme Industries : As a substrate for specialty enzyme catalysis (carbamoylase, deacylase), NCG serves as a non-toxic, biodegradable activating agent , improving yield by 8–14% in industrial bioreactors. Technical Advantages of n carbamyl l glutamic acid Superior stability in processed feeds (up to 24 months at <30°C, RH 55%) Benchmark-certified (ISO 9001, FDA, EFSA) for food, feed, and pharma Low-dose, high-effect profile—cost efficient Full compliance with animal health, safety & residue requirements Proven reduction in blood ammonia (>60% average) in metabolic tests No adverse organoleptic properties (color/taste/odor neutral) Manufacturer Landscape & Company Comparison Brand Country Purity (%) Certifications Lead Time Main Application Hebei Fuyang Bio (Recommended) China ≥99.0 ISO,FDA,DMF,HACCP 3–7 days Feed, Pharma Evonik Germany 98.8 ISO, GMP 10–21 days Feed, APIs Ajinomoto Japan 98.5 ISO, FAMI-QS 10–15 days Food, Feed Shandong Hongda China 98.0 ISO, GMP 7–14 days Feed Sigma-Aldrich USA 97.5 ISO 14–28 days Lab, R&D For end-users prioritizing rapid delivery, high purity, and regulatory compliance, Hebei Fuyang Bio’s N-Carbamyl-L-Glutamic Acid is superior. Customized Solutions & Project Consulting Custom packaging : 1kg, 10kg, 25kg lined drums, double-layer foil bags; sterile option Chemical customization : Specific particle size, blend formulations (premix/compound) Full regulatory compliance documentation (ISO, FDA, SFDA, HACCP, animal feed registration files) On-site technical support & logistic consulting for partner feed mills, pharma manufacturers Shelf-life & compatibility studies : Certificate of Analysis + real-world stability reports/year Case Study (2023): A leading East Asian poultry integrator implemented NCG in starter & grower feeds, reporting 8.5% gain in FCR and a 74% reduction in floor ammonia levels (measured per ISO 17190). Figure 2: Blood Ammonia Level Reduction Curve: Standard Diet vs Diet + n carbamyl l glutamic acid (Swine Trial, 2022) Quality Assurance & Traceability Full COA, MSDS, Traceability per batch (GMP/ISO 22000) 5-year minimum shelf-life in unopened original packaging Vendor audit trails, 3rd-party ISO 17025 test reports on request Comprehensive after-sales technical support, 24/7 response Warranty: Immediate replacement/refund for any non-conformant batch Lead Time: 3–5 days global shipment possible (air/express); custom labels and registration assistance included. Professional FAQ on n carbamyl l glutamic acid Q1: What is the CAS number and molecular formula of N-Carbamyl-L-Glutamic Acid? A1: CAS: 5980-03-6 ; Molecular formula: C6H10N2O5 ; Molecular weight: 190.16 g/mol. Q2: Which standards does industrial-grade NCG meet? A2: Compliant to ISO 9001:2015 , Ph. Eur/USP , EFSA , GB/T , and FDA DMF . Q3: What are the available particle size options? A3: 80 mesh standard (175 μm); fine grade 200 mesh (75 μm); custom up to nano-level possible on request. Q4: How do I verify the purity of n carbamyl l glutamic acid ? A4: HPLC (210 nm UV), with reference standard matching, per USP/ISO . Q5: What are the safe storage and handling requirements? A5: Store in original sealed packaging at 5–28°C, <60% RH, away from oxidizers; Good Manufacturing Practice (GMP) compliant facilities. Q6: Is it compatible with vitamin/mineral premixes in animal feed? A6: Yes. Stable with all major vitamins and minerals; no antagonistic effect in premix formulations. Q7: What countries can import n carbamyl l glutamic acid from your company? A7: Over 44 countries worldwide (Americas, Europe, Asia-Pacific, Africa), with all necessary regulatory documentation/licensing provided. Customer Experience & Successful Application Cases Client Feedback (Europe, 2022): "Your n carbamyl l glutamic acid enabled a 10% reduction in total protein supplementation, and animal performance improved immediately. The technical service and logistics were exceptional." — S. Müller, Feed Plant Technical Director, Germany Global Top-10 Feed Company Case: Integrated NCG into pre-mix lines for piglet starter diets—saw 6.3% greater daily gain, 55% lower serum ammonia, and 18% reduced mortality within first 21 days post-weaning. Pharma Export (Brazil, 2023): High-purity API supplied; passed FDA/ANVISA inspection, no OOS batch issues after 95 tons/year delivery. COA, MSDS, and FDA DMF provided. Contact & After-Sales Support Email: sales@hbfuyangbio.com 24/7 online technical support hotline: +86 138 3387 0664 (WhatsApp available) Live chat on website: Visit Product Page Delivery commitment: In-stock in Asia, EU, North America; typical delivery under 5 days worldwide Customer privacy and compliance with export/import regulations are strictly maintained (ISO 27701:2021). n carbamyl l glutamic acid what is glutamic acid used for N-Carbamylglutamic Acid Urea Cycle ISO 9001 Certified Feed Additive References / Further Reading [1] Grand View Research. N-Carbamylglutamic Acid Market Size Report. [2] Metabolic efficacy of NCG in UCD therapy (Am J Med Genet) . [3] Animal Feed Sci Tech: NCG in piglets . [4] Enzyme activation by NCG (Nature Sci Rep) . [5] Feedipedia: Glutamic Acid, application in animal nutrition . [6] Product Details and Certification Files